Anti-glycating and anti-oxidant compounds from traditionally used anti-diabetic plant Geigeria alata(DC) Oliv. & Hiern.

Abstract

A new sesquiterpene lactone geigerianoloide (1) and four known flavonoids axillarin (2), quercetin (3), 3-methoxy-5,7,3',4'-tetrahydroxy-flavone (4) and hispidulin (5) were isolated from Geigeria alata (DC) Oliv. & Hiern. (Asteraceae). Structures were deduced using ¹H- and ¹³C- NMR spectroscopy, mass spectrometry, while the structure of compound 1 was also deduced using X-ray crystallography technique.

Geigeria alata is traditionally used for diabetes, therefore compounds were tested for anti-glycation activity, in which compounds 2 and 3 showed potent activities (IC₅₀ values of 246.97?±?0.83 and 262.37?±?0.22 µM, respectively) compared to IC₅₀ value 294.50?±?1.5 µM of rutin. Moreover, compound 4 exhibited a comparable activity to rutin (IC₅₀?=?293.28?±?1.34 µM). Compound 5 showed a weak activity.

Compounds 2, 3, and 4 exhibited potent DPPH radical scavenging activity (IC₅₀?=?0.1?±?0.00, 0.13?±?0.00 and 0.15?±?0.01 µM, respectively). Compounds 2, 3, and 4 demonstrated significant superoxide anion scavenging activity with IC₅₀ values of 0.14?±?0.001, 0.17?±?0.00, and 0.11?±?0.006 µM, respectively.     

大气环境下的钢筋混凝土桥梁时变可靠度分析

为了探究钢筋混凝土桥梁抗力退化对桥梁可靠性能的影响,综合考虑一般大气环境下混凝土强度、钢筋强度、混凝土与钢筋黏结性能的降低,建立普通钢筋混凝土桥梁的抗力退化时变模型,分析规范车辆荷载作用的桥梁时变可靠度。研究结果表明,(1)一般大气环境下,桥梁抗力随着服役时间的增加而减小,其中钢筋强度退化对桥梁抗力的影响最大,其次是钢筋与混凝土黏结性能降低,而混凝土强度退化对桥梁抗力的影响相对较小; (2)桥梁可靠指标随着服役时间的增加而减小,密集行车占比越大,桥梁承载能力失效的概率就越大;非平稳车载作用下的桥梁可靠指标小于平稳车载,桥梁需要维修补强的时间比平稳车载提前; (3)多梁式简支梁桥在建造时应该提高边梁的安全储备,在管养时可以采取限载措施进行干预。     

阻尼对空爆荷载等效静载动力系数的影响

为考查阻尼参数对空爆荷载等效静载动力系数的影响,理论推导了空爆荷载下结构等效单自由体系弹塑性位移解及延性比解,设计并计算了阻尼比0.000 1～0.1、延性比1～4的20种典型工况的动力系数,并与现行抗爆设计规范动力系数公式结果进行了对比。结果表明:阻尼比小于0.000 1时可基本代表无阻尼状态,阻尼比0.01的动力系数比无阻尼的最大降低幅度为2.08%,数值差异很小,因此阻尼比为0.01以内时,可忽略阻尼对动力系数的影响;阻尼比0.05的动力系数比无阻尼的降低幅度约9.92%,数值差异较大,认为阻尼比0.05以上时将具有明显的经济效益;现行设计规范动力系数更适用于柔性结构体系,运用于刚性结构抗爆设计时,计算误差较大,对阻尼比较小的结构设计更不利。     

Nonlinear resonant tunneling diode (RTD) circuits for microwave A/D conversion

Short-duration electrical pulses play important roles in ultrafast time-domain metrology: they are used to sample rapidly varying signals or as probe signals in ranging radars, time-domain reflectometry and in communication. In this work, we design a nonlinear transmission, which is loaded with resonant tunneling diode to be suitable for microwave A/D conversion. A resonant tunneling diode (RTD) has a negative differential resistance that means when the voltage increases the current decreases. The equivalent circuit of monostable line is given. The simulation is performed by using OrCad program. Results show that a spike is produced and after a charging time constant, another switching occurs. Hence – similar to a relaxation oscillator – the spiking period is determined by the amplitude and frequency of the input current. The transmission line itself ensures the generation and propagation of identical spikes, such as solitons formed after few diodes.     

Collisional effects in the tokamap

Plasmas confined in tokamaks with non-symmetric perturbations are surrounded by a chaotic layer of magnetic field lines that guide charged particles to the tokamak wall. We use an analytical two-dimensional symplectic mapping to study the resulting fractal patterns of field line escape. However, particles may experience several collisions before escaping toward the tokamaks wall. We add a random collisional term to the field line mapping to investigate how the particle collisions modify their escape patterns.     

Determination of Trace Alkali and Alkaline Earth Metals in Orange Juice Using the DC Plasma and the Inductively Coupled Plasma Atomic Emission Techniques

Matrix effects in plasma spectroscopy have been measured in a simulated biological substrate. The authors show comparisons of such effects using both inductively coupled and direct current plasmas. The matrix influences are much more pronounced in direct current plasmas, but are also present when dealing with alkali metals in inductively coupled plasmas as well. The latter finding represents a particularly significant finding because it points the way to a method of determining alkali metals at levels of parts per billion.     

Electrical conduction mechanisms of thermally evaporated 5,10,15, 20-tetraphenyl-21H, 23H-porphine iron (III) chloride thin films

The J–V characteristics of the Au/5,10,15, 20-tetraphenyl-21H, 23H-porphine iron (III) chloride (FeTPPCl)/ITO device exhibits rectifying behavior in the dark which can be explained due to the formation of Schottky barrier at ITO/FeTPPCl junction and the typical junction parameters were estimated in temperatures from 302 to 368 K. The temperature dependence of DC electrical conductivity showed that FeTPPCl films behave as semiconducting materials. These results indicate that the DC electrical conduction is through an activated process having three conduction mechanisms in the investigated range of temperatures. A variable range hopping model, a polaron model and band to band transitions have been used to explain the conduction mechanisms for FeTPPCl films.     

Finding the buckling load of non-uniform columns using the iteration perturbation method

The aim of this study is to calculate the critical load of variable inertia columns. The example studied in this paper can be used as a paradigm for other non-uniform columns. The wavelength of equivalent vibratory system is used to calculate the critical load of the trigonometrically varied inertia column. In doing so, the equilibrium equation of the column is theoretically studied using the perturbation method. Accuracy of the calculated results is evaluated by comparing the solution with numerical results. Effect of improving the initial guess on the solution accuracy is investigated. Effects of varying parameters of the trigonometrically varied inertia and the uniformly tapered columns on their stability behavior are studied. Finally, using the so-called “perfectibility” parameter, two design goals, i.e., being lightweight and being strong, are studied for the discussed columns.     

Principal component analysis of the main factors of line intensity enhancements observed in oscillating direct current plasma

Enhancement of emission line intensities by induced oscillations of direct current (DC) arc plasma with continuous aerosol sample supply was investigated using multivariate statistics. Principal component analysis (PCA) was employed to evaluate enhancements of 34 atomic spectral lines belonging to 33 elements and 35 ionic spectral lines belonging to 23 elements. Correlation and classification of the elements were done not only by a single property such as the first ionization energy, but also by considering other relevant parameters. Special attention was paid to the influence of the oxide bond strength in an attempt to clarify/predict the enhancement effect. Energies of vaporization, atomization, and excitation were also considered in the analysis. In the case of atomic lines, the best correlation between the enhancements and first ionization energies was obtained as a negative correlation, with weak consistency in grouping of elements in score plots. Conversely, in the case of ionic lines, the best correlation of the enhancements with the sum of the first ionization energies and oxide bond energies was obtained as a positive correlation, with four distinctive groups of elements. The role of the gas-phase atom-oxide bond energy in the entire enhancement effect is underlined.